Phases of Prader-Willi Syndrome
Understanding the syndrome's evolution throughout life
Prader-Willi Syndrome is a condition that evolves over time. Recent studies have identified multiple distinct phases, each with specific characteristics.
Phase 0 - Prenatal
Decreased fetal movements, possible polyhydramnios (excess amniotic fluid).
Phase 1a - Birth to 9 months
Severe hypotonia, feeding difficulties, need for nutritional support (tube feeding).
Phase 1b - 9 to 25 months
Improvement in hypotonia, normal feeding and growth.
Phase 2a - 2 to 4.5 years
Weight gain without increased appetite or caloric intake.
Phase 2b - 4.5 to 8 years
Increased interest in food, but still with satiety.
Phase 3 - From 8 years old
Classic hyperphagia: insatiable appetite, constant food seeking, absence of satiety.
Phase 4 - Adults
Some adults may have reduced hyperphagia, but this varies.
Each person with PWS is unique. Not everyone goes through all phases or at the same intensity.
Phase Management
Understanding the phases allows for early and appropriate intervention at each stage.
Food restriction and a safe environment should be implemented BEFORE the onset of hyperphagia.